abstract：:The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour...

journal_title：British journal of cancer

authors： Mattern J,Bak M Jr,Hoever KH,Volm M

更新日期：1988-07-01 00:00:00

abstract：:Nuclear polyploidization in the livers of CF-1 mice, exposed to dieldrin (0, 1, 5 and 10 ppm in the diet), was studied up to the median time of liver tumour development (ranging from 15 to 27 months) in the respective treatment groups. In untreated controls nuclear polyploidization is characterized by a linear increas...

journal_title：British journal of cancer

authors： van Ravenzwaay B,Kunz W

更新日期：1988-07-01 00:00:00

abstract：:The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cells cultured in vitro...

journal_title：British journal of cancer

authors： Smith E,Brock AP

更新日期：1988-06-01 00:00:00

abstract：:Natural human interferon beta (beta-IFN) was tested during the early phase of in vitro infection with HTLV-I virus of human cord blood mononuclear cells (CBL), to evaluate whether its antiviral and immunomodulating effects might prevent spreading of infection in the host. beta-IFN was found to reduce HTLV-I transmissi...

journal_title：British journal of cancer

authors： D'Onofrio C,Perno CF,Mazzetti P,Graziani G,Calio' R,Bonmassar E

更新日期：1988-05-01 00:00:00

abstract：:The clearance of an intradermally-injected solution of 133Xenon in 0.9% saline has been used to study the impairment and recovery of blood flow in mouse tail for 5 days following photodynamic therapy (PDT) with 2mg TPPS i.v. per mouse and a range of doses of white light. Impairment of blood flow was observed within 10...

journal_title：British journal of cancer

authors： Benstead K,Moore JV

更新日期：1988-05-01 00:00:00

abstract：:The effect of the combined administration of doxorubicin (DX) and verapamil (VRP) on the induction of DX resistance of B16 melanoma cells, was investigated both in vitro and in vivo. Cells grown in the presence of increasing concentrations of DX and of 1 microM VRP, tested at several passages, were more resistant than...

journal_title：British journal of cancer

authors： Formelli F,Supino R,Cleris L,Mariani M

更新日期：1988-04-01 00:00:00

abstract：:In the BUPA Study, a prospective study of 22,000 men attending a screening centre in London, serum samples were collected and stored. The concentration of beta-carotene was measured in the stored serum samples from 271 men who were subsequently notified as having cancer and from 533 unaffected controls, matched for ag...

journal_title：British journal of cancer

authors： Wald NJ,Thompson SG,Densem JW,Boreham J,Bailey A

更新日期：1988-04-01 00:00:00

abstract：:In this study, the role of parity in conferring protection of the mammary gland against chemical carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA) was investigated. Experiments were also carried out to determine if an 'interrupted' pregnancy was capable of reducing the incidence of mammary tumour inducti...

journal_title：British journal of cancer

authors： Sinha DK,Pazik JE,Dao TL

更新日期：1988-04-01 00:00:00

abstract：:In a blind study, 518 serum samples were assayed for serum levels of mammary serum antigen (MSA) by an enzyme immunoassay (EIA) using the 3E1.2 monoclonal antibody. Using 300 IU as the arbitrary cut off to distinguish normal from abnormal individuals, 75% of patients with primary Stage I carcinoma of the breast (n = 1...

journal_title：British journal of cancer

authors： Stacker SA,Sacks NP,Golder J,Tjandra JJ,Thompson CH,Smithyman A,McKenzie IF

更新日期：1988-03-01 00:00:00

abstract：:Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen lev...

journal_title：British journal of cancer

authors： Dowsett M,Shearer RJ,Ponder BA,Malone P,Jeffcoate SL

更新日期：1988-02-01 00:00:00

abstract：:Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and d...

journal_title：British journal of cancer

authors： Fukatsu T,Sobue M,Nagasaka T,Ohiwa N,Fukata S,Nakashima N,Takeuchi J

更新日期：1988-01-01 00:00:00

abstract：:The modulating effect of 43 degrees C hyperthermia on the induction of oncogenic transformation by the antineoplastic agents, actinomycin D, mitomycin C, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was examined using the C3H 10T1/2 cell line. For any given level of cytotoxicity, cells exposed to the three chemothe...

journal_title：British journal of cancer

authors： Komatsu K,Miller RC,Hall EJ

更新日期：1988-01-01 00:00:00

abstract：:Several studies of breast tumour histology and oestrogen receptor (ER) contents report an inverse correlation between the density of the stromal lymphoid cell infiltrate and the presence or concentration of ER. Using monoclonal antibodies to lymphoid cell surface markers we have examined the immunophenotype of the inf...

journal_title：British journal of cancer

authors： Underwood JC,Giri DD,Rooney N,Lonsdale R

更新日期：1987-12-01 00:00:00

abstract：:The risk for sinonasal cancer associated with tobacco use was examined in a case-control study in males diagnosed between 1978 and 1981 in the Netherlands. Of the 116 cases of sinonasal cancer and 259 controls identified, interviews were completed for 92 (79%) of the cases and 195 (75%) of the controls. Ever-users of ...

journal_title：British journal of cancer

authors： Hayes RB,Kardaun JW,de Bruyn A

更新日期：1987-12-01 00:00:00

abstract：:The behaviour in vivo of tight and loose variants of murine melanoma cells is further characterized. In vitro clonal morphology is reproduced on a variety of substrates. Results suggest that repeated selection of loose cells can co-select for cells with high metastatic and colonization potentials. Measurement of cell ...

journal_title：British journal of cancer

authors： Clark SR,Brody JS,Sidebottom E

更新日期：1987-11-01 00:00:00

abstract：:Cellular DNA was analysed by flow cytometry in fine needles aspirates (FNA) from both benign and malignant breast lesions in order to determine the feasibility of flow cytometric analysis. In 22 of 26 (84%) benign and 69 of 74 (93%) malignant aspirates, sufficient cells were present to produce good quality DNA histogr...

journal_title：British journal of cancer

authors： Levack PA,Mullen P,Anderson TJ,Miller WR,Forrest AP

更新日期：1987-11-01 00:00:00

abstract：:To assist in the description of the cellular heterogeneity present in normal and neoplastic urothelium, a panel of monoclonal antibodies (MoAbs) was raised against human transitional cell carcinoma (TCC) of the urinary bladder. All immunizations were carried out using whole cells and membrane preparations from well di...

journal_title：British journal of cancer

authors： Dotsikas G,Konowalchuk T,Major PP,Kovac PE,Ward GK,Stewart SS,Price GB,Elhilali MM,Mackillop WJ

更新日期：1987-10-01 00:00:00

abstract：:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...

journal_title：British journal of cancer

authors： Giaccone G,Bagatella M,Donadio M,Bonardi GM,Testore F,Ferrati P,Ciuffreda L,Calciati A

更新日期：1987-10-01 00:00:00

abstract：:We have employed molecular probes produced from DNA fragments of human papillomavirus, cloned into prokaryotic vectors, to detect virus nucleic acid sequences in extracts of human oral tissues. The study was conducted with duplicate coded snap-frozen tissue biopsies from which frozen sections had been taken to accurat...

journal_title：British journal of cancer

authors： Maitland NJ,Cox MF,Lynas C,Prime SS,Meanwell CA,Scully C

更新日期：1987-09-01 00:00:00

abstract：:Chinese hamster V79-171B spheroids implanted in the peritoneal cavity of C3H mice were characterized as a model for evaluating the toxicity of drugs requiring metabolic activation in vivo. After 24 hours in the peritoneal cavity, spheroid cellularity and plating efficiency were not significantly decreased, and host ce...

journal_title：British journal of cancer

authors： Olive PL

更新日期：1987-09-01 00:00:00

abstract：:A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well character...

journal_title：British journal of cancer

authors： Lindahl T

更新日期：1987-08-01 00:00:00

abstract：:Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in E...

journal_title：British journal of cancer

authors： Schirrmacher V,Josimovic-Alasevic O,Osawa H,Diamantstein T

更新日期：1987-06-01 00:00:00

abstract：:Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' b...

journal_title：British journal of cancer

authors： Iles RK,Oliver RT,Kitau M,Walker C,Chard T

更新日期：1987-06-01 00:00:00

abstract：:The appearance of a liver DNA synthesis promoter (HP) in rat plasma after dimethylnitrosamine (DMNA) or thioacetamide injection was investigated. After 48 h, DMNA (30 mg kg-1 body weight) produced liver (centrilobular) necrosis and intense hepatic regeneration, as assessed by microscopic observations of liver slices, ...

journal_title：British journal of cancer

authors： Díaz-Gil JJ,Sánchez G,Santamaría L,Trilla C,Esteban P,Escartín P,Gea T

更新日期：1987-06-01 00:00:00

abstract：:Choriocarcinoma can be imaged by external scintigraphy after intravenous administration of radiolabelled antibody directed against human chorionic gonadotrophin (HCG). The purpose of this study was to investigate whether antibody imaging was sufficiently sensitive and specific to improve the selection of patients for ...

journal_title：British journal of cancer

authors： Begent RH,Bagshawe KD,Green AJ,Searle F

更新日期：1987-06-01 00:00:00

abstract：:The reaction patterns of eight antibodies directed against blood group substances A, B and H, respectively, against Lewis B antigen, difucosylated carbohydrate antigens (DFCA), gastrointestinal cancer antigen CA 19-9 (GICA), carcinoma-associated antigen CA-50 and CEA, were studied in 68 rectal carcinomas using the avi...

journal_title：British journal of cancer

authors： Enblad P,Glimelius B,Busch C,Pontén J,Påhlman L

更新日期：1987-05-01 00:00:00

abstract：:We have investigated the effects of 50 min whole-body hyperthermia (WBH; 15 min equilibration followed by 41 degrees C for 35 min) on the toxicity and pharmacokinetics of the radiosensitizer Ro 03-8799 in mice. WBH markedly reduced Ro 03-8799 LD50/7d from 779 to 259 micrograms g-1 (P less than 0.001). Pharmacokinetics...

journal_title：British journal of cancer

authors： Walton MI,Bleehen NM,Workman P

更新日期：1987-05-01 00:00:00

abstract：:It has recently been reported that a series of testis cancers shows a temporal cycle in birth dates with a peak in certain months. This observation has been tested by an examination of a larger series covering all testis cancers diagnosed in the years 1971-84 in England and Wales, in men born in 1940 or later. Limited...

journal_title：British journal of cancer

authors： Kinlen LJ,Willows AN

更新日期：1987-05-01 00:00:00

abstract：:Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...

journal_title：British journal of cancer

authors： Thein SL,Jeffreys AJ,Gooi HC,Cotter F,Flint J,O'Connor NT,Weatherall DJ,Wainscoat JS

更新日期：1987-04-01 00:00:00

abstract：:To test the hypothesis that steroid hormone receptor expression is particularly pronounced in breast tumours when compared with non-neoplastic tissue, mastectomy samples were divided into 16 sectors. Multifocal tumours, of varying receptor phenotype were found in 4 patients and in addition different regions of large t...

journal_title：British journal of cancer

authors： Panahy C,Puddefoot JR,Anderson E,Vinson GP,Berry CL,Turner MJ,Brown CL,Goode AW

更新日期：1987-04-01 00:00:00

abstract：:In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...

journal_title：British journal of cancer

authors： Siddik ZH,Boxall FE,Harrap KR

更新日期：1987-04-01 00:00:00

abstract：:Postoperative hyperplasia enhances experimental intestinal carcinogenesis, but the effects of nonsurgical adaptation are uncertain. The tropic and tumour-promoting potentials of moderate hypothermia were tested in two groups of male Sprague-Dawley rats housed at 10 degrees C for 30 weeks. One group (n = 10) received a...

journal_title：British journal of cancer

authors： Rainey JB,Davies PW,Williamson RC

更新日期：1987-03-01 00:00:00

abstract：:We have studied the cytotoxic effects of recombinant tumour necrosis factor and recombinant gamma interferon on primary cultures of leukaemia cells. The agents were added alone or in a combination to cells from 17 patients. Eleven had acute myeloblastic leukaemia (6 at presentation, 5 at relapse), 4 had acute lymphobl...

journal_title：British journal of cancer

authors： Price G,Brenner MK,Prentice HG,Hoffbrand AV,Newland AC

更新日期：1987-03-01 00:00:00

abstract：:Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progr...

journal_title：British journal of cancer

authors： Yang TJ,Chandler JP,Dunne-Anway S

更新日期：1987-02-01 00:00:00

abstract：:The relationship between breast self examination (BSE) and breast cancer stage at diagnosis was examined in 616 women aged 15-59 years. Differences in tumour characteristics between those not practising BSE and those practising but not taught were small and inconstant. However, women who had both practised and had bee...

journal_title：British journal of cancer

authors： Mant D,Vessey MP,Neil A,McPherson K,Jones L

更新日期：1987-02-01 00:00:00

abstract：:The effect of LiCl on melanoma cell growth and differentiation was studied in mouse and human melanoma cell lines. LiCl markedly inhibited B16 and HT-144 melanoma cell growth in vitro. Clonogenicity in soft agar of the melanoma cells was also markedly inhibited by LiCl. Pretreatment of B16 mouse melanoma cells with Li...

journal_title：British journal of cancer

authors： Nordenberg J,Panet C,Wasserman L,Malik Z,Fuchs A,Stenzel KH,Novogrodsky A

更新日期：1987-01-01 00:00:00

abstract：:The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...

journal_title：British journal of cancer

authors： Adami HO,Krusemo UB,Bergkvist L,Persson I,Pettersson B

更新日期：1987-01-01 00:00:00

abstract：:The influence of anthracyclines on membrane permeability functions has been investigated in HeLa cells by monitoring the efflux of fluorescein. Release of the fluorescent dye, dependent on the metabolic energy supply, occurs after the intracellular accumulation and enzymatic hydrolysis of the non-fluorescent substrate...

journal_title：British journal of cancer

authors： Croce AC,Prosperi E,Supino R,Bottiroli G

更新日期：1986-12-01 00:00:00

abstract：:During the period 1943-1980 a significant increase in the incidence of neuroblastoma was seen in Denmark. The incidence increased from a level corresponding to that in Finland to a level corresponding to that in the USA, and the increase appears to be continuing. The increase relates to children aged under 5 years, an...

journal_title：British journal of cancer

authors： Carlsen NL

更新日期：1986-12-01 00:00:00

abstract：:L-Glutamine is a requirement for many cells in tissue culture, an intermediate in many metabolic pathways, and an alternative substrate to glucose for energy metabolism. These properties suggest that glutamine concentration might be a determinant of cell viability in tumours, especially in regions that are deficient i...

journal_title：British journal of cancer

authors： Tannock IF,Steele D,Roberts J

更新日期：1986-11-01 00:00:00